Journal article
Circulating Heat Shock Protein 60 Levels Are Elevated in HIV Patients and Are Reduced by Anti-Retroviral Therapy
I Anraku, R Rajasuriar, C Dobbin, R Brown, SR Lewin, A Suhrbier
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 ..
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Funding Acknowledgements
The work was funded by grants from the Australian Centre for HIV and Hepatitis Virology Research (http://napwa.org.au/services/australian-centre-for-hiv-and-hepatitis-virology-research-ach2) and the Australian Research Council (http://www.arc.gov.au/). AS is a Principle Research Fellow and SL is a Practitioner Fellow with the National Health and Medical Research Council, Australia (http://www.nhmrc.gov.au/grants). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.